Claire Barnabe was born on November 13, 1940 in Eastview (now Vanier), Ontario. She attended Our Lady of the Presentation in Overbrook for elementary school and Eastview High School in Vanier for secondary school. Claire was a member of the religious order of Holy Cross for four years. She attended Ottawa Teachers' College and obtained a permanent Ontario Teachers' Certificate. She taught at an elementary school in Alexandria, Ontario, Iona Academy in St. Raphael’s West, Ontario, for the Catholic School Board in Montreal, and for the Separate School Board in Ottawa before moving north.
In 1965, she accepted a teaching position at Fort Franklin (now Deline), where she worked until 1967. During her time in Deline, she was also Secretary of the Community Club. In 1968, after spending a year in the south and touring Europe, Claire returned to the north to work as a teacher in Fort Providence. She was also President of the Community Club there and Chairman of the NWT Centennial Planning Committee for Fort Providence.
In 1969, she left her teaching position in Fort Providence and moved to Norman Wells where she worked at the Mackenzie Mountain Lodge. She moved back to Fort Providence later that year to work for Alex Arychuk, also in the hotel business. In the 1970 Territorial election, she ran as a candidate for the Lower Mackenzie riding. Following her defeat in the election, she applied to work as a Settlement Manager.
In May 1971, she accepted the position of settlement manager in Port Burwell on Killinek Island, where she remained until May 1973. After a very brief time as Settlement Manager at Large for the Baffin Region, she became the Settlement Manager at Repulse Bay (now Naujaat, Nunavut). Also in 1973, she was appointed to be a member of the NWT Historical Advisory Board. In 1974, Claire returned to Norman Wells as Settlement Manager there. She ran in the 1975 Territorial election and the 1976 by-election for the riding of Mackenzie Great Bear, but was defeated both times.
She took leave from the GNWT in 1976 to work on a Master’s degree in Public Administration at Carleton University, Ottawa. In 1978, she joined Bud Drury’s office as a policy analyst. She ran again in the 1979 Territorial election for the riding of Yellowknife Centre and was again defeated. Claire remained in the north for many more years, before retiring to the south.